OMEGA-3 YAĞ ASİTLERİNİN OBEZİTEYE BAĞLI NÖROBİYOLOJİK VE DAVRANIŞSAL DEĞİŞİKLİKLER ÜZERİNDEKİ ROLÜ

Abdel-Maksoud, S. M., Hassanein, S. I., Gohar, N. A., Attia, S. M. M. ve Gad, M. Z. (2017). Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids. Nutritional Neuroscience, 20(8), 443–448. https://doi.org/10.1080/1028415X.2016.1180859

Agrawal, R. ve Gomez-Pinilla, F. (2012). 'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. The Journal of Physiology, 590(10), 2485–2499. https://doi.org/10.1113/jphysiol.2012.230078

Ahima, R. S. ve Antwi, D. A. (2008). Brain regulation of appetite and satiety. Endocrinology and Metabolism Clinics of North America, 37(4), 811–823. https://doi.org/10.1016/j.ecl.2008.08.005

Artmann, A., Petersen, G., Hellgren, L. I., Boberg, J., Skonberg, C., Nellemann, C., Hansen, S. H. ve Hansen, H. S. (2008). Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. Biochimica et Biophysica Acta, 1781(4), 200–212. https://doi.org/10.1016/j.bbalip.2008.01.006

Auguste, S., Sharma, S., Fisette, A., Fernandes, M. F., Daneault, C., Des Rosiers, C. ve Fulton, S. (2018). Perinatal deficiency in dietary omega-3 fatty acids potentiates sucrose reward and diet-induced obesity in mice. International Journal of Developmental Neuroscience: The Official Journal of the International Society for Developmental Neuroscience, 64, 8–13. https://doi.org/10.1016/j.ijdevneu.2017.09.003

Banni, S. ve Di Marzo, V. (2010). Effect of dietary fat on endocannabinoids and related mediators: Consequences on energy homeostasis, inflammation and mood. Molecular Nutrition & Food Research, 54(1), 82–92. https://doi.org/10.1002/mnfr.200900516

Bargut, T. C., Mandarim-de-Lacerda, C. A. ve Aguila, M. B. (2015). A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice. The Journal of Nutritional Biochemistry, 26(9), 960–969. https://doi.org/10.1016/j.jnutbio.2015.04.002

Barks, J. D., Liu, Y., Shangguan, Y., Djuric, Z., Ren, J. ve Silverstein, F. S. (2017). Maternal high-fat diet influences outcomes after neonatal hypoxic-ischemic brain injury in rodents. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 37(1), 307–318. https://doi.org/10.1177/0271678X15624934

Batetta, B., Griinari, M., Carta, G., Murru, E., Ligresti, A., Cordeddu, L., Giordano, E., Sanna, F., Bisogno, T., Uda, S., Collu, M., Bruheim, I., Di Marzo, V. ve Banni, S. (2009). Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. The Journal of Nutrition, 139(8), 1495–1501. https://doi.org/10.3945/jn.109.104844

Bauché, F., Sabourault, D., Giudicelli, Y., Nordmann, J. ve Nordmann, R. (1981). 2-Mercaptoacetate administration depresses the beta-oxidation pathway through an inhibition of long-chain acyl-CoA dehydrogenase activity. The Biochemical Journal, 196(3), 803–809. https://doi.org/10.1042/bj1960803

Bazinet, R. P.ve Layé, S. (2014). Polyunsaturated fatty acids and their metabolites in brain function and disease. Nature reviews. Neuroscience, 15(12), 771–785. https://doi.org/10.1038/nrn3820

Berridge K. C. (2009). 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders. Physiology & Behavior, 97(5), 537–550. https://doi.org/10.1016/j.physbeh.2009.02.044

Bourre J. M. (2004). Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing. The Journal of Nutrition, Health & Aging, 8(3), 163–174.

Buettner, R., Schölmerich, J. ve Bollheimer, L. C. (2007). High-fat diets: Modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring, Md.), 15(4), 798–808. https://doi.org/10.1038/oby.2007.608

Calder P. C. (2017). Omega-3 fatty acids and inflammatory processes: From molecules to man. Biochemical Society Transactions, 45(5), 1105–1115. https://doi.org/10.1042/BST20160474

Campfield, L. A. ve Smith, F. J. (1986). Functional coupling between transient declines in blood glucose and feeding behavior: Temporal relationships. Brain Research Bulletin, 17(3), 427–433. https://doi.org/10.1016/0361-9230(86)90250-9

Cascio M. G. (2013). PUFA-derived endocannabinoids: An overview. The Proceedings of the Nutrition Society, 72(4), 451–459. https://doi.org/10.1017/S0029665113003418

Castanon, N., Lasselin, J. ve Capuron, L. (2014). Neuropsychiatric comorbidity in obesity: Role of inflammatory processes. Frontiers in Endocrinology, 5, 74. https://doi.org/10.3389/fendo.2014.00074

Chalon S. (2006). Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 75(4-5), 259–269. https://doi.org/10.1016/j.plefa.2006.07.005

Chalon, S., Vancassel, S., Zimmer, L., Guilloteau, D. ve Durand, G. (2001). Polyunsaturated fatty acids and cerebral function: Focus on monoaminergic neurotransmission. Lipids, 36(9), 937–944. https://doi.org/10.1007/s11745-001-0804-7

Cintra, D. E., Ropelle, E. R., Moraes, J. C., Pauli, J. R., Morari, J., Souza, C. T., Grimaldi, R., Stahl, M., Carvalheira, J. B., Saad, M. J. ve Velloso, L. A. (2012). Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PloS One, 7(1), e30571. https://doi.org/10.1371/journal.pone.0030571

Citrome L. (2019). Binge eating disorder revisited: What's new, what's different, what's next. CNS Spectrums, 24(S1), 4–13. https://doi.org/10.1017/S1092852919001032

Convit A. (2012). Obesity is associated with structural and functional brain abnormalities: Where do we go from here?. Psychosomatic Medicine, 74(7), 673–674. https://doi.org/10.1097/PSY.0b013e3182662c56

D'Asti, E., Long, H., Tremblay-Mercier, J., Grajzer, M., Cunnane, S. C., Di Marzo, V. ve Walker, C. D. (2010). Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring. Endocrinology, 151(4), 1685–1694. https://doi.org/10.1210/en.2009-1092

de Andrade, A. M., Fernandes, M. D. C., de Fraga, L. S., Porawski, M., Giovenardi, M. ve Guedes, R. P. (2017). Omega-3 fatty acids revert high-fat diet-induced neuroinflammation but not recognition memory impairment in rats. Metabolic Brain Disease, 32(6), 1871–1881. https://doi.org/10.1007/s11011-017-0080-7

de Mello, A. H., Schraiber, R. B., Goldim, M. P. S., Garcez, M. L., Gomes, M. L., de Bem Silveira, G., Zaccaron, R. P., Schuck, P. F., Budni, J., Silveira, P. C. L., Petronilho, F. ve Rezin, G. T. (2019). Omega-3 Fatty Acids Attenuate Brain Alterations in High-Fat Diet-Induced Obesity Model. Molecular Neurobiology, 56(1), 513–524. https://doi.org/10.1007/s12035-018-1097-6

Deane, K. H. O., Jimoh, O. F., Biswas, P., O'Brien, A., Hanson, S., Abdelhamid, A. S., Fox, C. ve Hooper, L. (2021). Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: Systematic review and meta-analysis of randomised trials. The British Journal of Psychiatry: The Journal of Mental Science, 218(3), 135–142. https://doi.org/10.1192/bjp.2019.234

Dearden, L. ve Balthasar, N. (2014). Sexual dimorphism in offspring glucose-sensitive hypothalamic gene expression and physiological responses to maternal high-fat diet feeding. Endocrinology, 155(6), 2144–2154. https://doi.org/10.1210/en.2014-1131

Demers, G., Roy, J., Machuca-Parra, A. I., Dashtehei Pour, Z., Bairamian, D., Daneault, C., Rosiers, C. D., Ferreira, G., Alquier, T., Fulton, S. ve Representative of consortium (2020). Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice. International Journal of Obesity, 44(9), 1936–1945. https://doi.org/10.1038/s41366-020-0623-6

Di Marzo V. (2008). Endocannabinoids: Synthesis and degradation. Reviews of Physiology, Biochemistry and Pharmacology, 160, 1–24. https://doi.org/10.1007/112_0505

Di Marzo, V., Griinari M., Carta G., vd.. (2010). Dietary krill oil increases docosahexaenoic acid and reduces 2-arachidonoylglycerol but not N-acylethanolamine levels in the brain of obese Zucker rats. Int Dairy J, (20), 231-235. https://doi.org/10.1016/j.idairyj.2009.11.015

Drougard, A., Fournel, A., Valet, P. ve Knauf, C. (2015). Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake. Frontiers in Neuroscience, 9, 56. https://doi.org/10.3389/fnins.2015.00056

Elphick M. R. (2012). The evolution and comparative neurobiology of endocannabinoid signalling. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 367(1607), 3201–3215. https://doi.org/10.1098/rstb.2011.0394

Fan, R., Hua, Y., Shen, J., Xiao, R. ve Ma, W. (2022). Dietary fatty acids affect learning and memory ability via regulating inflammatory factors in obese mice. The Journal of Nutritional Biochemistry, 103, 108959. https://doi.org/10.1016/j.jnutbio.2022.108959

Farooqui A. A. (2012). N-3 fatty acid-derived lipid mediators in the brain: New weapons against oxidative stress and inflammation. Current Medicinal Chemistry, 19(4), 532–543. https://doi.org/10.2174/092986712798918851

Fedorova, I. ve Salem, N., Jr (2006). Omega-3 fatty acids and rodent behavior. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 75(4-5), 271–289. https://doi.org/10.1016/j.plefa.2006.07.006

Friedman, M. I. ve Stricker, E. M. (1976). The physiological psychology of hunger: A physiological perspective. Psychological Review, 83(6), 409–431. https://doi.org/10.1037/0033-295X.83.6.409

Fulton S. (2010). Appetite and reward. Frontiers in Neuroendocrinology, 31(1), 85–103. https://doi.org/10.1016/j.yfrne.2009.10.003

Gao, H., Geng, T., Huang, T. ve Zhao, Q. (2017). Fish oil supplementation and insulin sensitivity: A systematic review and meta-analysis. Lipids in Health and Disease, 16(1), 131. https://doi.org/10.1186/s12944-017-0528-0

Golub, N., Geba, D., Mousa, S. A., Williams, G.ve Block, R. C. (2011). Greasing the wheels of managing overweight and obesity with omega-3 fatty acids. Medical Hypotheses, 77(6), 1114–1120. https://doi.org/10.1016/j.mehy.2011.09.016

Hotamisligil G. S. (2006). Inflammation and metabolic disorders. Nature, 444(7121), 860–867. https://doi.org/10.1038/nature05485

Howie, G. J., Sloboda, D. M., Reynolds, C. M. ve Vickers, M. H. (2013). Timing of maternal exposure to a high fat diet and development of obesity and hyperinsulinemia in male rat offspring: Same metabolic phenotype, different developmental pathways?. Journal of Nutrition and Metabolism, 2013, 517384. https://doi.org/10.1155/2013/517384

Johnson, A. R., Milner, J. J. ve Makowski, L. (2012). The inflammation highway: Metabolism accelerates inflammatory traffic in obesity. Immunological Reviews, 249(1), 218–238. https://doi.org/10.1111/j.1600-065X.2012.01151.x

Kapoor, B., Kapoor, D., Gautam, S., Singh, R. ve Bhardwaj, S. (2021). Dietary polyunsaturated fatty acids (PUFAs): Uses and potential health benefits. Current Nutrition Reports, 10(3), 232–242. https://doi.org/10.1007/s13668-021-00363-3

Kislal, S., Jin, W., Maesner, C. ve Edlow, A. G. (2021). Mismatch between obesogenic intrauterine environment and low-fat postnatal diet may confer offspring metabolic advantage. Obesity Science & Practice, 7(4), 450–461. https://doi.org/10.1002/osp4.501

Kislal, S., Shook, L. L. ve Edlow, A. G. (2020). Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring. Prenatal Diagnosis, 40(9), 1109–1125. https://doi.org/10.1002/pd.5784

Layé, S., Nadjar, A., Joffre, C. ve Bazinet, R. P. (2018). Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology. Pharmacological Reviews, 70(1), 12–38. https://doi.org/10.1124/pr.117.014092

Lee, J. M., Lee, H., Kang, S. ve Park, W. J. (2016). Fatty acid desaturases, polyunsaturated fatty acid regulation, and biotechnological advances. Nutrients, 8(1), 23. https://doi.org/10.3390/nu8010023

Li, M., Reynolds, C. M., Sloboda, D. M., Gray, C. ve Vickers, M. H. (2013). Effects of taurine supplementation on hepatic markers of inflammation and lipid metabolism in mothers and offspring in the setting of maternal obesity. PloS One, 8(10), e76961. https://doi.org/10.1371/journal.pone.0076961

Lumeng, C. N. ve Saltiel, A. R. (2011). Inflammatory links between obesity and metabolic disease. The Journal of Clinical Investigation, 121(6), 2111–2117. https://doi.org/10.1172/JCI57132

Mathai, M. L., Soueid, M., Chen, N., Jayasooriya, A. P., Sinclair, A. J., Wlodek, M. E., Weisinger, H. S. ve Weisinger, R. S. (2004). Does perinatal omega-3 polyunsaturated fatty acid deficiency increase appetite signaling?. Obesity Research, 12(11), 1886–1894. https://doi.org/10.1038/oby.2004.234

Matias, I. ve Di Marzo, V. (2007). Endocannabinoids and the control of energy balance. Trends in Endocrinology and Metabolism: TEM, 18(1), 27–37. https://doi.org/10.1016/j.tem.2006.11.006

Muñoz, A. ve Costa, M. (2013). Nutritionally mediated oxidative stress and inflammation. Oxidative Medicine and Cellular Longevity, 2013, 610950. https://doi.org/10.1155/2013/610950

Noble, E. E., Billington, C. J., Kotz, C. M. ve Wang, C. (2011). The lighter side of BDNF. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 300(5), R1053–R1069. https://doi.org/10.1152/ajpregu.00776.2010

Pimentel, G. D., Lira, F. S., Rosa, J. C., Oller do Nascimento, C. M., Oyama, L. M., Harumi Watanabe, R. L. ve Ribeiro, E. B. (2013). High-fat fish oil diet prevents hypothalamic inflammatory profile in rats. ISRN Inflammation, 2013, 419823. https://doi.org/10.1155/2013/419823

Segovia, S. A., Vickers, M. H., Gray, C. ve Reynolds, C. M. (2014). Maternal obesity, inflammation, and developmental programming. BioMed Research International, 2014, 418975. https://doi.org/10.1155/2014/418975

Sharma, S., Zhuang, Y. ve Gomez-Pinilla, F. (2012). High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour. Scientific Reports, 2, 431. https://doi.org/10.1038/srep00431

Shefer, G., Marcus, Y. ve Stern, N. (2013). Is obesity a brain disease?. Neuroscience and Biobehavioral Reviews, 37(10 Pt 2), 2489–2503. https://doi.org/10.1016/j.neubiorev.2013.07.015

Shook, L. L., Kislal, S. ve Edlow, A. G. (2020). Fetal brain and placental programming in maternal obesity: A review of human and animal model studies. Prenatal Diagnosis, 40(9), 1126-1137. https://doi.org/10.1002/pd.5724

Silvestri, C. ve Di Marzo, V. (2013). The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders. Cell Metabolism, 17(4), 475–490. https://doi.org/10.1016/j.cmet.2013.03.001

Souza, C. G., Moreira, J. D., Siqueira, I. R., Pereira, A. G., Rieger, D. K., Souza, D. O., Souza, T. M., Portela, L. V. ve Perry, M. L. (2007). Highly palatable diet consumption increases protein oxidation in rat frontal cortex and anxiety-like behavior. Life Sciences, 81(3), 198–203. https://doi.org/10.1016/j.lfs.2007.05.001

Sugasini, D. ve Lokesh, B. R. (2015). Rats given linseed oil in microemulsion forms enriches the brain synaptic membrane with docosahexaenoic acid and enhances the neurotransmitter levels in the brain. Nutritional Neuroscience, 18(2), 87–96. https://doi.org/10.1179/1476830514Y.0000000111

Suzuki, S., Akechi, T., Kobayashi, M., Taniguchi, K., Goto, K., Sasaki, S., Tsugane, S., Nishiwaki, Y., Miyaoka, H. ve Uchitomi, Y. (2004). Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer. British Journal of Cancer, 90(4), 787–793. https://doi.org/10.1038/sj.bjc.6601621

Thaler, J. P., Yi, C. X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., Nguyen, H. T., Fischer, J. D., Matsen, M. E., Wisse, B. E., Morton, G. J., Horvath, T. L., Baskin, D. G., Tschöp, M. H. ve Schwartz, M. W. (2012). Obesity is associated with hypothalamic injury in rodents and humans. The Journal of Clinical Investigation, 122(1), 153–162. https://doi.org/10.1172/JCI59660

Türkiye Endokrinoloji ve Metabolizma Derneği (TEMD). (2018). Obezite Tanı ve Tedavi Kılavuzu. Obezite tedavisinde bilişsel davranışçı terapi. 6. Baskı. Ankara, Miki Matbaacılık San. ve Tic. Ltd. Şti.; s:77- 79.http://www.temd.org.tr/admin/uploads/tbl_gruplar/20180525144116-2018-05-25tbl_gruplar144108.pdf. Erişim tarihi 24 Ocak 2023.

Türkiye İstatistik Kurumu (TÜİK). (2019). Türkiye Sağlık Araştırması. https://data.tuik.gov.tr/Bulten/Index?p=Turkiye-Saglik-Arastirmasi-2019-33661. Erişim tarihi 24 Ocak 2023.

Vieau, D., Sebaai, N., Léonhardt, M., Dutriez-Casteloot, I., Molendi-Coste, O., Laborie, C., Breton, C., Deloof, S. ve Lesage, J. (2007). HPA axis programming by maternal undernutrition in the male rat offspring. Psychoneuroendocrinology, 32 Suppl 1, S16–S20. https://doi.org/10.1016/j.psyneuen.2007.03.014

Viggiano, E., Mollica, M. P., Lionetti, L., Cavaliere, G., Trinchese, G., De Filippo, C., Chieffi, S., Gaita, M., Barletta, A., De Luca, B., Crispino, M. ve Monda, M. (2016). Effects of an High-Fat Diet Enriched in Lard or in Fish Oil on the Hypothalamic Amp-Activated Protein Kinase and Inflammatory Mediators. Frontiers in Cellular Neuroscience, 10, 150. https://doi.org/10.3389/fncel.2016.00150

Watanabe, S., Doshi, M. ve Hamazaki, T. (2003). N-3 polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 PUFA enrichment reduces brain 2-arachidonoylglycerol level in mice. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 69(1), 51–59. https://doi.org/10.1016/s0952-3278(03)00056-5

Willemsen, L. E., Koetsier, M. A., Balvers, M., Beermann, C., Stahl, B. ve van Tol, E. A. (2008). Polyunsaturated fatty acids support epithelial barrier integrity and reduce IL-4 mediated permeability in vitro. European Journal of Nutrition, 47(4), 183–191. https://doi.org/10.1007/s00394-008-0712-0

Williams L. M. (2012). Hypothalamic dysfunction in obesity. The Proceedings of the Nutrition Society, 71(4), 521–533. https://doi.org/10.1017/S002966511200078X

World Health Organization (WHO). (2021). Obesity and Overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Erişim tarihi 24 Ocak 2023.

Wu, A., Ying, Z. ve Gomez-Pinilla, F. (2008). Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience, 155(3), 751–759. https://doi.org/10.1016/j.neuroscience.2008.05.061

Yoshida, R., Ohkuri, T., Jyotaki, M., Yasuo, T., Horio, N., Yasumatsu, K., Sanematsu, K., Shigemura, N., Yamamoto, T., Margolskee, R. F. ve Ninomiya, Y. (2010). Endocannabinoids selectively enhance sweet taste. Proceedings of the National Academy of Sciences of the United States of America, 107(2), 935–939. https://doi.org/10.1073/pnas.0912048107

Zhang, Y. Y., Liu, W., Zhao, T. Y. ve Tian, H. M. (2017). Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: A meta-analysis of randomized clinical trials. The Journal of Nutrition, Health & Aging, 21(2), 187–192. https://doi.org/10.1007/s12603-016-0755-5

Ziemens, D., Touma, C. ve Rappeneau, V. (2022). Neurobiological mechanisms modulating emotionality, cognition and reward-related behaviour in high-fat diet-fed rodents. International Journal of Molecular Sciences, 23(14), 7952. https://doi.org/10.3390/ijms23147952